ORIGINAL RESEARCH article
Front. Plant Sci.
Sec. Plant Metabolism and Chemodiversity
Volume 16 - 2025 | doi: 10.3389/fpls.2025.1613313
Biosynthesis-based metabolomics analysis reveals chemical diversity between two Salvia species
Provisionally accepted
- 1Zhejiang Sci-Tech University, Hangzhou, China
- 2Fudan University, Shanghai, Shanghai Municipality, China
- 3Naval Medical University, Shanghai, Shanghai, China
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Salvia officinalis is an important dietary supplement that is widely used as flavor regulators and plays an important role in prevention and treatment of neurodegenerative diseases. Salvia miltiorrhiza Bunge is a famous Chinese herbal medicine for treating cardiovascular diseases.Secondary metabolites with diverse structures endow the two species with various edible and medicinal values. However, the differences in secondary metabolites between leaves of S. officinalis and S. miltiorrhiza are still unclear. Herein, FlavourSpec® combined with spatial metabolomics was used to explore the distribution patterns of secondary metabolites including volatile and non-volatile components. The results indicated that the chemical compositions of the two Salvia species were significantly different. Specifically, S. miltiorrhiza Bunge contained high levels of phenolic acid components with furan ring that can hardly be detected in S. officinalis. The volatile small molecules as well as carnosic acid and derivatives were found to be major components of S. officinalis leaves.Due to the long-term exposure of leaves to ultraviolet radiation and the same environmental stress, carnosic acid and its derivatives exhibit widespread distribution characteristics in S. officinalis leaves.The work explored the similarities and differences in secondary metabolites of S. officinalis and S. miltiorrhiza Bunge, providing not only the material basis to develop the application value in dietary nutrition, but also a theoretical foundation for the development and utilization of medicinal resources of Salvia.
Keywords: Spatial metabolome, Chemical diversity, Volatile components，Phenolic acids, Carnosic acid，Salvia officinalis, Salvia miltiorrhiza bunge
Received: 17 Apr 2025; Accepted: 29 May 2025.
Copyright: © 2025 Wang, Li, Yu, Yang, Ji and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lei Zhang, Zhejiang Sci-Tech University, Hangzhou, China
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