Frontiers in Toxicology

Original Research

Published on 13 Nov 2025

Biological analysis of Sonchus oleraceus (Linn) extract and its effect on mitigating sodium benzoate-induced cytotoxicity and genotoxicity

Maryam Abdulmalik Althubyani
Abdulmajeed F. Alrefaei
Sameer Hasan Qari
Rayan S. Alharbi
Aljawharah Alqathama

Frontiers in Toxicology

doi 10.3389/ftox.2025.1674822

1,779 views

Original Research

Published on 11 Nov 2025

Toxicological assessment of Chlorella vulgaris and its potential preventive effect in a chronic obstructive pulmonary disease (COPD) mouse model

Lucia Giambastiani
Sofia Fiorentino
Kylie Brady
Andrea Raffaelli
Emilia Bramanti
Erna Cecilia Lorenzini
Vincenzo Longo
Francesca Sparvoli
Luisa Pozzo
Andrea Vornoli

Frontiers in Toxicology

doi 10.3389/ftox.2025.1654583

1,715 views

Editorial

Published on 07 Nov 2025

Editorial: Magnetic resonance imaging contrast agents: the safety of gadolinium

John Sy
Joshua DeAguero
Brent Wagner

Frontiers in Toxicology

doi 10.3389/ftox.2025.1664840

3,959 views

Original Research

Published on 06 Nov 2025

Diagnostic value of GPX4, IL-13, periostin, and thiol/disulfide balance in adult patients with scorpion envenomation: a prospective observational study

Hasan Buyukaslan
Şenay Koçakoğlu

Frontiers in Toxicology

doi 10.3389/ftox.2025.1697677

953 views

Original Research

Published on 05 Nov 2025

Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds

R. R. Sillito
J. Sutherland
A. Milne
C. Giuliano
C. Sigfridsson
M. Rolf
A. K. Cherian
M. McClafferty
E. I. Rossman
G. Teuns

Frontiers in Toxicology

doi 10.3389/ftox.2025.1655330

3,303 views

Original Research

Published on 05 Nov 2025

Exposure to the herbicide glyphosate leads to inappropriate threat responses and alters gut microbial composition

Mauricio Cáceres-Chacón
Osmarie Martínez-Guzmán
Héctor A. Haddock-Martínez
Alexdiel Figueroa-Pérez
Sian Rodríguez-Rosado
Jaleniz Suárez-Pérez
Raúl Y. Ramos-Sánchez
Filipa Godoy-Vitorino
Demetrio Sierra-Mercado

Frontiers in Toxicology

doi 10.3389/ftox.2025.1704231

2,341 views

Original Research

Published on 03 Nov 2025

Comprehensive methodology for standardized ecotoxicological assessment of TiO2-based sunscreen leachates in aquatic environment

Roberta Nugnes
Giulia De Negri Atanasio
Elisabetta Perata
Erica Lertora
Lorenzo Dondero
Federica Robino
Francesca Tardanico
Cristina Capelli
Fabio Ghioni
Tania Cai

Frontiers in Toxicology

doi 10.3389/ftox.2025.1686954

1,582 views

Original Research

Published on 30 Oct 2025

Montmorillonite-based essential oil carrier and its effects on non-target species: an environmental perspective on its risk assessment

Sofia Machado
Catarina Ganilho
Tatiana Andreani
Rose Marie O. F. Sousa
Artur Ribeiro
Ruth Pereira

Frontiers in Toxicology

doi 10.3389/ftox.2025.1696913

1,133 views
1 citation

Original Research

Published on 30 Oct 2025

Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions

Katharina S. Nitsche
Paul L. Carmichael
Sophie Malcomber
Iris Müller
Hans Bouwmeester

Frontiers in Toxicology

doi 10.3389/ftox.2025.1649393

2,739 views
1 citation

Review

Published on 30 Oct 2025

Developing an approach for evaluating the cardiotoxic potential of botanicals

Julie Krzykwa
Hemantkumar S. Chaudhari
Andre Monteiro Da Rocha
Matthias Gossmann
Peter Hoffmann
Yaser Khokhar
Nathan Meyer
Jin-Young K. Park
Robert Sprando
Ravi Vaidyanathan

Frontiers in Toxicology

doi 10.3389/ftox.2025.1646044

2,727 views
1 citation

Original Research

Published on 28 Oct 2025

A toxicological assessment of Hericium erinaceus (Lion’s mane) and Trametes versicolor (Turkey tail) mushroom powders

Kritika Mahadevan
Julie Daoust
Thomas Brendler
Ankit Chaudhary
Alimuddin Saifi
Vipin Kumar Garg

Frontiers in Toxicology

doi 10.3389/ftox.2025.1651442

4,457 views
2 citations

Original Research

Published on 20 Oct 2025

Toxicological and nutritional evaluation of plant cell cultures from scurvy grass (Cochlearia danica) and rowan (Sorbus aucuparia)

Felicianna
Ho Lam Cheung
Emily Kwun Kwan Lo
Fangfei Zhang
Hoi Kit Matthew Leung
Marsena Jasiel Ismaiah
Natalia Rosa-Sibakov
Valeria Iannone
Carlos Gómez-Gallego
Marjukka Kolehmainen

Frontiers in Toxicology

doi 10.3389/ftox.2025.1655489

1,908 views
1 citation

Original Research

Published on 20 Oct 2025

Toxicological effects of sublethal microcystin-LR exposure in Labeo rohita: histopathological, ultrastructural, immunological, and biochemical impairments

Snatashree Mohanty
Anirban Paul
K. V. Rajendran
Gayatri Tripathi
Pratap Chandra Das
Pramoda Kumar Sahoo

Frontiers in Toxicology

doi 10.3389/ftox.2025.1658995

1,631 views

Original Research

Published on 17 Oct 2025

Phenotypically anchored transcriptomics across diverse agrichemicals reveals conserved pathways and unique gene expression signatures in zebrafish

Lindsey St. Mary
Ryan McClure
Lisa Truong
Steven J. Carrell
Katrina M. Waters
Robyn L. Tanguay

Frontiers in Toxicology

doi 10.3389/ftox.2025.1675060

1,903 views

Original Research

Published on 17 Oct 2025

Danger on the plate: human health risks derived from the consumption of angular angelshark (Squatina guggenheim) meat in southeastern Brazil

Amanda Pontes Lopes
Rebeca Dias de Souza Coutinho
Tatiana Dillenburg Saint’Pierre
Rachel Ann Hauser-Davis

Frontiers in Toxicology

doi 10.3389/ftox.2025.1645858

1,558 views

Original Research

Published on 15 Oct 2025

A short-term sublethal oral exposure to microcystin-LR disrupts cecal microbiome homeostasis in mallard

Serguei V. Drovetski
Valerie I. Shearn-Bochsler
Erik K. Hofmeister
Natalie K. Karouna-Renier
Robert J. Dusek

Frontiers in Toxicology

doi 10.3389/ftox.2025.1634241

1,196 views

Original Research

Published on 14 Oct 2025

Intravenously administered iron oxide nanoparticles with different coatings reversibly perturb immune cells in peripheral blood without inducing toxicity in mice

Preethi Korangath
Chun-Ting Yang
Sean Healy
Cordula Grüttner
Kathleen Gabrielson
Robert Ivkov

Frontiers in Toxicology

doi 10.3389/ftox.2025.1673416

1,714 views

Perspective

Published on 13 Oct 2025

Refining the safety assessment of newly expressed proteins in GMOs

Elena Sánchez-Brunete
Arianna Ferrari
F. Javier Moreno
Tilemachos Goumperis
Michele Ardizzone
Reinhilde Schoonjans
Ian Dewhurst
Ivan Dimitrov
Michelle M. Epstein
Frits Koning

Frontiers in Toxicology

doi 10.3389/ftox.2025.1679506

2,324 views

Original Research

Published on 08 Oct 2025

Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

Jessica Ryman
Richard A. Becker

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657708

1,872 views

Review

Published on 07 Oct 2025

Advancing human health risk assessment: the role of new approach methodologies

Deepika Deepika
Kanchan Bharti
Shubh Sharma
Saurav Kumar
Rajesh Kumar Pathak
Judit Biosca Brull
Oscar Sabuz
Silvia García Vilana
Vikas Kumar

Frontiers in Toxicology

doi 10.3389/ftox.2025.1632941

3,698 views
3 citations

Original Research

Published on 03 Oct 2025

Characterizing chlorotriazine effects in cancer-relevant high-throughput screening assays

Agnes L. Karmaus
Alex Charlton

Frontiers in Toxicology

doi 10.3389/ftox.2025.1682439

1,373 views

Review

Published on 03 Oct 2025

Pesticides, an urgent challenge to global environmental health and planetary boundaries

Laura N. Vandenberg
Elise J. Pierce
Rachel M. Arsenault

Frontiers in Toxicology

doi 10.3389/ftox.2025.1656297

4,128 views
2 citations

Original Research

Published on 01 Oct 2025

Hospital admissions for acute drug poisoning in adults and children: a 7-year retrospective analysis of hospital discharges at a tertiary center

Daniel Wang
Lina Camacho-Arteaga
Rosario Muñoz Gallarín
Immaculada Danés
Antònia Agustí Escasany

Frontiers in Toxicology

doi 10.3389/ftox.2025.1672470

2,017 views

Original Research

Published on 01 Oct 2025

Proliferation and metabolic activity of the Atlantic sturgeon cell line AOXlar7y under short-term serum-reduced conditions, and the effect of stimulation with growth factors and cytokines

Valeria Di Leonardo
Julia Brenmoehl
Heike Wanka
Bianka Grunow

Frontiers in Toxicology

doi 10.3389/ftox.2025.1636776

1,741 views

645 Publications

volumes

Volume 7 - 2025

Biological analysis of Sonchus oleraceus (Linn) extract and its effect on mitigating sodium benzoate-induced cytotoxicity and genotoxicity

Toxicological assessment of Chlorella vulgaris and its potential preventive effect in a chronic obstructive pulmonary disease (COPD) mouse model

Editorial: Magnetic resonance imaging contrast agents: the safety of gadolinium

Diagnostic value of GPX4, IL-13, periostin, and thiol/disulfide balance in adult patients with scorpion envenomation: a prospective observational study

Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds

Exposure to the herbicide glyphosate leads to inappropriate threat responses and alters gut microbial composition

Comprehensive methodology for standardized ecotoxicological assessment of TiO2-based sunscreen leachates in aquatic environment

Montmorillonite-based essential oil carrier and its effects on non-target species: an environmental perspective on its risk assessment

Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions

Developing an approach for evaluating the cardiotoxic potential of botanicals

A toxicological assessment of Hericium erinaceus (Lion’s mane) and Trametes versicolor (Turkey tail) mushroom powders

Toxicological and nutritional evaluation of plant cell cultures from scurvy grass (Cochlearia danica) and rowan (Sorbus aucuparia)

Toxicological effects of sublethal microcystin-LR exposure in Labeo rohita: histopathological, ultrastructural, immunological, and biochemical impairments

Phenotypically anchored transcriptomics across diverse agrichemicals reveals conserved pathways and unique gene expression signatures in zebrafish

Danger on the plate: human health risks derived from the consumption of angular angelshark (Squatina guggenheim) meat in southeastern Brazil

A short-term sublethal oral exposure to microcystin-LR disrupts cecal microbiome homeostasis in mallard

Intravenously administered iron oxide nanoparticles with different coatings reversibly perturb immune cells in peripheral blood without inducing toxicity in mice

Refining the safety assessment of newly expressed proteins in GMOs

Reproduction of the human relevant potency threshold (HRPT) for estrogen receptor alpha agonism in an inference performance screen for ICCVAM’s regulatory scientific confidence framework

Advancing human health risk assessment: the role of new approach methodologies

Characterizing chlorotriazine effects in cancer-relevant high-throughput screening assays

Pesticides, an urgent challenge to global environmental health and planetary boundaries

Hospital admissions for acute drug poisoning in adults and children: a 7-year retrospective analysis of hospital discharges at a tertiary center

Proliferation and metabolic activity of the Atlantic sturgeon cell line AOXlar7y under short-term serum-reduced conditions, and the effect of stimulation with growth factors and cytokines