CORRECTION article

Front. Plant Sci., 13 August 2018

Sec. Plant Metabolism and Chemodiversity

Volume 9 - 2018 | https://doi.org/10.3389/fpls.2018.01178

Corrigendum: Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials

  • Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia

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In the original article Fürst and Zündoft, 2014 was not cited in the article. The citation has now been inserted in section Immunomodulators, Paragraph 3 and should read:

“Recently the clinical potential of six plant-derived anti-inflammatory compounds: curcumin, colchicine, resveratrol, capsaicin, epigallocatechin-3-gallate (EGCG), and quercetin has been highlighted Fürst and Zündoft (2014). The present review will give an overview of these widely investigated plant-derived compounds including andrographolide and genistein, which have exhibited potent effects on cellular and humoral immune functions in pre-clinical investigations and will highlight their clinical potential.”

The citation has now been inserted in section Curcumin, Paragraph 2 and should read:

“However, Fürst and Zündoft (2014) suggested that these are preliminary clinical trials which are frequently too weak and of low quality to draw a conclusion due to the low number of enrolled patients, which normally ranges from 10 to 30. As suggested by the authors, more operationally thorough and serious randomized controlled trials are required to evaluate the compound as an effective and safe agent for human use. It is worth mentioning that curcumin suffers from its low bioavailability, though substantial improvement has been made to address this issue via chemical and technological methods (Anand et al., 2007).”

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.

The original article has been updated.

Statements

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  • 1

    AnandP.KunnumakkaraA. B.NewmanR. A.AggarwalB. B. (2007). Bioavailability of curcumin: problems and promises. Mol. Pharm.4, 807818. 10.1021/mp700113r

  • 2

    FürstR.ZündoftI. (2014). Plant-derived anti-inflammatory compounds: Hopes and dissapointments regarding the translation of preclinical knowledge into clinical progress. Mediat. Inflamm.2014:146832. 10.1155/2014/146832

Summary

Keywords

immunomodulation, curcumin, resveratrol, epigallocatechol-3-gallate, quercetin, colchicine, capsaicin

Citation

Jantan I, Ahmad W and Bukhari SNA (2018) Corrigendum: Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front. Plant Sci. 9:1178. doi: 10.3389/fpls.2018.01178

Received

16 July 2018

Accepted

23 July 2018

Published

13 August 2018

Approved by

Frontiers in Plant Science, Frontiers Media SA, Switzerland

Volume

9 - 2018

Updates

Copyright

*Correspondence: Ibrahim Jantan

This article was submitted to Plant Metabolism and Chemodiversity, a section of the journal Frontiers in Plant Science

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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