Frontiers in Immunology | Viral Immunology

Original Research

Published on 11 Dec 2025

Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment

in Viral Immunology

Mauro Voi
Antonella Sangalli
Erica Ginevra Milano
Carola De Martinis
Elisa Orlandi
Stefano Tamburin
Elisa Mantovani
Angela Federico
Massimiliano Lanzafame
Emanuela Lattuada

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703026

1,359 views

Original Research

Published on 09 Dec 2025

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1

in Viral Immunology

Zhongwen Hu
Hossam Abdelrahman
Abdelrahman Elwy
Fei Kuang
Swati Dhiman
Shafaqat Ali
Marcel Marson
Lisa Holnsteiner
Thamer A. Hamdan
Justa Friebus-Kardash

Frontiers in Immunology

doi 10.3389/fimmu.2025.1638403

2,554 views

Original Research

Published on 09 Dec 2025

Modulation of TLR7, TYK2 and OAS1 expression during SARS-CoV-2 infection

in Viral Immunology

Estíbaliz Alegría-Carrasco
Marta Jaén-Castaño
Pablo Delgado-Wicke
Nelly D. Zurita-Cruz
Nuria Montes
Emilia Roy-Vallejo
Sara Fernández de Córdoba-Oñate
Ana Nicolao-Gómez
Rosa Carracedo-Rodríguez
Ana Marcos-Jiménez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1713928

1,165 views

Original Research

Published on 08 Dec 2025

The local cellular response to Human Papillomavirus focuses on basal layer restoration as visualized in situ by specific cellular neighborhoods near infected cells

in Viral Immunology

Roderick C. Slieker
Ziena Abdulrahman
Saskia Santegoets
Mariette I. E. van Poelgeest
Marij J. P. Welters
Sjoerd H. van der Burg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1728629

1,587 views

Review

Published on 05 Dec 2025

Viral manipulation of the HLA class I antigen processing and presentation pathway

in Viral Immunology

Dominic S Nolan
Arwen F Altenburg

Frontiers in Immunology

doi 10.3389/fimmu.2025.1694498

1,813 views
1 citation

Original Research

Published on 05 Dec 2025

Transcriptome analysis of differences in the infection of African swine fever virus (SY-1 strain) in iPAMs and PAMs

in Viral Immunology

Haiying Mao
Chuxing Cheng
Yong Wang
Wenhui Zhou
Ke Zhang
Yongqi Wang
Lihao Wang
Zhenrui Song
Xiaomei Sun
Yuanfeng Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692373

1,384 views

Systematic Review

Published on 02 Dec 2025

High prevalence of baseline Non-R5 viral tropism in PLWH is associated with immune damage: a systematic review and meta-analysis

in Viral Immunology

Yangyang Liu
Defu Yuan
Yueqi Yin
Qian He
Meng Zhao
Hongfei Ma
Pingmin Wei
You Ge

Frontiers in Immunology

doi 10.3389/fimmu.2025.1701028

1,237 views

Brief Research Report

Published on 02 Dec 2025

Latent reservoirs in memory T cell subsets are linked to poor immune recovery in people living with HIV

in Viral Immunology

Selwyn Selva Kumar
John Paul Demosthenes
Madheswaran A.
Milton P.
Inbanathan A.
Nagaraj V.
Abi Manesh
Saravanabhavan Thangavel
Luke Elizabeth Hanna
Rajesh Kannangai

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684924

1,756 views

Original Research

Published on 28 Nov 2025

Single‐cell transcriptomics reveals pathogen interactions and T cell reprogramming in HIV and Mycobacterium tuberculosis co‐infection

in Viral Immunology

Zihui Zhao
Suyue Huang
Wei Huang
Wei Song
Li Liu
Jun Chen
Renfang Zhang
Yinzhong Shen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680538

2,172 views

Mini Review

Published on 28 Nov 2025

Dysregulated TFEB–autophagy-lysosome pathway links acute COVID-19 immunopathology to Long COVID sequelae

in Viral Immunology

Magdalena Gabig-Cimińska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1708364

1,740 views

Review

Published on 28 Nov 2025

Hidden players of COVID-19: the evolving roles of SARS-CoV-2 accessory proteins

in Viral Immunology

Miguel Padilla-Blanco
Tránsito García-García
Juozas Grigas
Blanca D. López-Ayllón
Juan J. Garrido
María A. Oliva
María Montoya

Frontiers in Immunology

doi 10.3389/fimmu.2025.1726698

2,660 views

Case Report

Published on 28 Nov 2025

Human herpesvirus 6B infection in an adult with hemophagocytic lymphohistiocytosis carrying an UNC13D mutation: a case report and literature review

in Viral Immunology

Pingping Xiao
Qingqing Wang
Tingting Li
Zhigao Dong
Junnan Su
Yongquan Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679372

1,066 views

Original Research

Published on 28 Nov 2025

Impact of HCV cure on systemic inflammation and bone density, quality, and turnover

in Viral Immunology

Christina K. Psomas
Elsa Lellouche-Slama
Susan Langan
Mark Sulkowski
Kendall F. Moseley
Jenny Pena-Dias
Smita Khati
Jing Sun
Alison G. Abraham
Todd T. Brown

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626875

1,273 views

Original Research

Published on 28 Nov 2025

Convalescent plasma therapy for COVID-19 prophylaxis in adults early post-hematopoietic stem cell transplantation: one-year outcomes from a randomized controlled trial

in Viral Immunology

Yigeng Cao
Qiang Li
Wenwen Guo
Mingyue Xu
Kuo Fang
Fengjiao Wang
Rongli Zhang
Lin Li
Jialin Wei
Zhenyun Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1626775

1,262 views

Review

Published on 26 Nov 2025

MIS-C pathogenesis: immune dysregulation & viral triggers

in Viral Immunology

Tiantian Xu
Jiamin Zhang
Xiangyuan Hou
Xinyu Xie
Junye Qi
Changbing Wang
Yuqing Yan
Lu Kuang
Bing Zhu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624963

1,546 views

Original Research

Published on 25 Nov 2025

A comprehensive longitudinal analysis of the cellular immune response specific to the spike protein in healthcare workers vaccinated against SARS-CoV-2– ORCHESTRA Project

in Viral Immunology

Stefano Ugel
Akshita Gupta
Gianluca Spiteri
Pierpaolo Marchetti
Francesco De Sanctis
Shari Wouters
Angelina Konnova
Maria Grazia Lourdes Monaco
Angela Carta
Maria Diletta Pezzani

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707449

1,568 views

Original Research

Published on 25 Nov 2025

TCR repertoire of human cytotoxic CD4 T cells responding to betaherpesviruses HHV-6B and HCMV

in Viral Immunology

Aniuska Becerra-Artiles
Grant C. Weaver
Peter O. Oluoch
Lawrence J. Stern

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631558

1,782 views

Original Research

Published on 21 Nov 2025

Coordinated kinetics of humoral, T-cell, and cytokine responses to SARS-COV-2 in West African healthcare workers: a multicenter longitudinal study in university hospitals of Abidjan, Côte d’Ivoire

in Viral Immunology

Amah Patricia Victorine Goran-Kouacou
Oppong Richard Yéboah
Yida Jocelyne Séri
Aya Ursule Aniela Assi
Adjoumanvoulé Honoré Adou
Salimata Moussa
Brou Doris Oura
Koffi N’Guessan
Kouabla Liliane Siransy
Séry Romuald Dassé

Frontiers in Immunology

doi 10.3389/fimmu.2025.1669517

955 views

Review

Published on 20 Nov 2025

Exosomes at the crossroads of HIV-1 pathogenesis and therapeutics

in Viral Immunology

Pengpeng Lu
Xu Lin
Wenyi Yang
Junhao Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634726

1,755 views

Original Research

Published on 19 Nov 2025

Analysis of blood proteome in influenza-infected patients reveals new insights into the host response signatures distinguishing mild severe infections

in Viral Immunology

Klaus Schughart
Stephen C. Threlkeld
Subhashini A. Sellers
Willam A. Fischer
Jens Schreiber
Eva Lücke
Mark Heise
Amber M Smith

Frontiers in Immunology

doi 10.3389/fimmu.2025.1693728

1,496 views
1 citation

Original Research

Published on 19 Nov 2025

Transplacental transferred anti-SARS-CoV-2 neutralizing antibodies in unvaccinated pregnant women in Cameroon occurred during the COVID-19 pandemic, but not in the pre-pandemic period

in Viral Immunology

Reine Medouen Ndeumou Seumko’o
Thandeka Moyo-Gwete
Tandile Hermanus
Sosthene Hillary Matabou Tene
Romeo Brice Dieffouo Djounda
Chris Marco Mbianda Nana
Bernard Marie Zambo Bitye
Tekougang Berenice Kenfack Zangue
Bodin Darcisse Kwanou Tchakounte
Eitel Mpoudi Ngolle

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628102

1,603 views

Original Research

Published on 19 Nov 2025

Comparing human pediatric immune responses to primary infection with dengue, chikungunya and Zika viruses

in Viral Immunology

Lewis E Tomalin
Sandra Bos
Rafael Fenutria
Yitong Chen
Seunghee Kim-Schulze
Adeeb H Rahman
Angel Balmaseda
Ana Fernandez-Sesma
Eva Harris
Mayte Suaréz-Fariñas

Frontiers in Immunology

doi 10.3389/fimmu.2025.1679566

1,804 views

Original Research

Published on 18 Nov 2025

Methionine enkephalin upregulates toll-like receptors in macrophages to suppress severe fever with thrombocytopenia syndrome virus infection

in Viral Immunology

Jing Tian
Zhuping Ma
Xiaomeng Wang
Yonggang Li
Yulian Mu
Xiaoli Tao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700988

1,844 views

Original Research

Published on 18 Nov 2025

Development of nanobody-based DAS-ELISA and Au nanoparticle-based immunochromatographic test strip for highly sensitive detection of Chikungunya virus

in Viral Immunology

Mengmeng Guo
Liyuan Song
Jingliang Liu
Yating Hu
Yihui Chen
Guangcheng Fu
Hongyu Yuan
Jianmin Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1707358

1,958 views

2,752 articles

articles

Computational characterization of peptide binding stability to HLA-C allotypes and its association with HIV-1 infection progression and HIV-1 related neurocognitive impairment

Acid ceramidase regulates CD8+ T-cell exhaustion via type I interferon-mediated upregulation of PD-L1

Modulation of TLR7, TYK2 and OAS1 expression during SARS-CoV-2 infection

The local cellular response to Human Papillomavirus focuses on basal layer restoration as visualized in situ by specific cellular neighborhoods near infected cells

Viral manipulation of the HLA class I antigen processing and presentation pathway

Transcriptome analysis of differences in the infection of African swine fever virus (SY-1 strain) in iPAMs and PAMs

High prevalence of baseline Non-R5 viral tropism in PLWH is associated with immune damage: a systematic review and meta-analysis

Latent reservoirs in memory T cell subsets are linked to poor immune recovery in people living with HIV

Single‐cell transcriptomics reveals pathogen interactions and T cell reprogramming in HIV and Mycobacterium tuberculosis co‐infection

Dysregulated TFEB–autophagy-lysosome pathway links acute COVID-19 immunopathology to Long COVID sequelae

Hidden players of COVID-19: the evolving roles of SARS-CoV-2 accessory proteins

Human herpesvirus 6B infection in an adult with hemophagocytic lymphohistiocytosis carrying an UNC13D mutation: a case report and literature review

Impact of HCV cure on systemic inflammation and bone density, quality, and turnover

Convalescent plasma therapy for COVID-19 prophylaxis in adults early post-hematopoietic stem cell transplantation: one-year outcomes from a randomized controlled trial

MIS-C pathogenesis: immune dysregulation & viral triggers

A comprehensive longitudinal analysis of the cellular immune response specific to the spike protein in healthcare workers vaccinated against SARS-CoV-2– ORCHESTRA Project

TCR repertoire of human cytotoxic CD4 T cells responding to betaherpesviruses HHV-6B and HCMV

Coordinated kinetics of humoral, T-cell, and cytokine responses to SARS-COV-2 in West African healthcare workers: a multicenter longitudinal study in university hospitals of Abidjan, Côte d’Ivoire

Exosomes at the crossroads of HIV-1 pathogenesis and therapeutics

Analysis of blood proteome in influenza-infected patients reveals new insights into the host response signatures distinguishing mild severe infections

Transplacental transferred anti-SARS-CoV-2 neutralizing antibodies in unvaccinated pregnant women in Cameroon occurred during the COVID-19 pandemic, but not in the pre-pandemic period

Comparing human pediatric immune responses to primary infection with dengue, chikungunya and Zika viruses

Methionine enkephalin upregulates toll-like receptors in macrophages to suppress severe fever with thrombocytopenia syndrome virus infection

Development of nanobody-based DAS-ELISA and Au nanoparticle-based immunochromatographic test strip for highly sensitive detection of Chikungunya virus