Frontiers in Immunology | Viral Immunology

Original Research

Published on 22 Sep 2025

HIV subtype-specific gp140-CD4 binding, Temsavir efficacy, and identification of novel adhesion inhibitors against Chinese HIV strains

in Viral Immunology

Tianyang Liu
Xiaowen Li
Xiaolin Yang
Shengjie Zhang
Yao Wang
Siwei Zhang
Lin Cheng
Shanshan Tang
Fuxiang Wang
Yao Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1648546

2,134 views

Original Research

Published on 22 Sep 2025

Antiviral and immunomodulatory effect of zapnometinib in animal models and hospitalized COVID-19 patients

in Viral Immunology

Yvonne Füll
Lara M. Schüssele
Hazem Hamza
Helen Hoffmann
Martin Bauer
Stephan Stenglein
Oliver Pötz
Andreas Steinhilber
Viktoria Anselm
Mark W. Delany

Frontiers in Immunology

doi 10.3389/fimmu.2025.1631721

2,807 views
2 citations

Original Research

Published on 19 Sep 2025

Impact of pregnant mothers’ previous COVID-19 infection and vaccination on newborns’ serological profiling

in Viral Immunology

Alaa Masry
Mohammad A. A. Bayoumi
Prem Chandra
Hana J. Abukhadijah
Tawa Olukade
Ismail Abdelhady
Sudheer Thazhe
Ratheesh Paramban
Anoop Sudarsanan
Jeat Abraham

Frontiers in Immunology

doi 10.3389/fimmu.2025.1526264

2,969 views
1 citation

Mini Review

Published on 18 Sep 2025

HIV and the gut: implications for HIV persistence, immune dysfunction and cure strategies

in Viral Immunology

Jillian S. Y. Lau
Sharon R. Lewin
Sushama Telwatte

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650852

5,699 views
3 citations

Review

Published on 18 Sep 2025

Host proteases: key regulators in viral infection and therapeutic targeting

in Viral Immunology

Qiongrong Xia
Xiaohua Liu
Huacui Huang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1671173

3,615 views
4 citations

Original Research

Published on 17 Sep 2025

Transcriptomic and proteomic profiling reveal immune and metabolic dysregulation in the colonic mucosa of people living with HIV with incomplete immune recovery

in Viral Immunology

Mari Kaarbø
Mingyi Yang
Malin Holm Meyer-Myklestad
Arvind Y. M. Sundaram
Mirta Mittelstedt Leal de Sousa
Animesh Sharma
Asle W. Medhus
Anne Margarita Dyrhol-Riise
Dag Kvale
Johannes R. Hov

Frontiers in Immunology

doi 10.3389/fimmu.2025.1635523

3,510 views

Original Research

Published on 17 Sep 2025

Association between human herpesvirus 6 status and sarcopenia risk: a UK biobank cohort study with sex-specific patterns and telomere length modification

in Viral Immunology

Xiangliang Liu
Wang Yang
Xinqiao Chen
Yuting Liu
Yixin Zhao
Yuguang Li
Naifei Chen
Jiuwei Cui

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623291

2,323 views

Brief Research Report

Published on 17 Sep 2025

Serum matters: human platelet lysate enables physiological modeling of HIV-1 infection in dendritic cells

in Viral Immunology

Paul Schweighofer
Magdalena Erlacher
Wilfried Posch
Doris Wilflingseder

Frontiers in Immunology

doi 10.3389/fimmu.2025.1661425

1,767 views

Systematic Review

Published on 17 Sep 2025

Immunogenicity and safety of the booster COVID-19 vaccine among people with HIV: a systematic review and meta-analysis

in Viral Immunology

Zhenzhen Chen
Chunping Wan
Bing Chen
Qingyan Mo
Mingqian Ju
Kunlong Deng
Xiaohong Li
Dongdong Qin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1668576

2,666 views
2 citations

General Commentary

Published on 12 Sep 2025

Commentary: Long COVID in pediatric age: an observational, prospective, longitudinal, multicenter study in Italy

in Viral Immunology

Cristiana Indolfi
Angela Klain
Giulio Dinardo
Carolina Grella
Maria Maddalena Marrapodi
Michele Miraglia del Giudice

Frontiers in Immunology

doi 10.3389/fimmu.2025.1624011

1,089 views

Review

Published on 04 Sep 2025

HIV-associated depression: a translational framework targeting neuroimmune inflammation and psychosocial stress modulation

in Viral Immunology

Fei Yu
Yue Zhu
Yiran Fan
Mingqi Chen
Qing Peng
Shenghao Li
Liyuan Hao
Fanghang Ye
Jiajun Xia
Xiaoyu Hu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1645991

4,399 views

Original Research

Published on 03 Sep 2025

Advanced aggressive clinical features may be associated with immune dysfunction in patients with HIV-positive Hodgkin lymphoma in the cART era: a multicenter study from China

in Viral Immunology

Xiping Liang
Chaoyu Wang
Yifeng Tang
Xiaoqing Xie
Yan Wu
Haiyan Min
Wei Zhang
Wenwen Zhou
Vishnu Prasad Adhikari
Xiaomei Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1628909

2,147 views

Case Report

Published on 02 Sep 2025

Human cytomegalovirus infection-induced lymphocytosis diagnosed by metagenomic next-generation sequencing: a case report and literature review

in Viral Immunology

Shaofan Zhang
Li Sun
Liman Wang
Yuwei Liu
Gao Tan
Tao Liu
Wen Yang
Xiaoli Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637085

2,540 views

Original Research

Published on 02 Sep 2025

Co-expression of PD1+ and HLA-DR+ in CD8+ T cells is increased in tonsils of children with EBV primary and persistent infection

in Viral Immunology

María Eugenia Amarillo
Karen Lindl
Veronica Lapido
Ignacio E. Rojas Campión
M. Soledad Collado
Johanna Speratti
Andrea Valerio
Plácida Baz
Elena De Matteo
L. Ariel Billordo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1653165

2,392 views
1 citation

Systematic Review

Published on 01 Sep 2025

Cure of chronic hepatitis C virus infection after DAA treatment only partially restores the functional capacity of exhausted T cell subsets: a systematic review

in Viral Immunology

Ása Didriksen Apol
Christina Sølund
Caroline Vinten
Alexander P. Underwood
Jens Bukh
Nina Weis

Frontiers in Immunology

doi 10.3389/fimmu.2025.1546915

3,134 views
2 citations

Review

Published on 01 Sep 2025

The emerging role of extracellular vesicles in viral transmission and immune evasion

in Viral Immunology

Muhammad Saleem
Chieh-Wei Chang
Abdul Qadeer
Mohammed Asiri
Fuad M. Alzahrani
Khalid J. Alzahrani
Khalaf F. Alsharif
Chien-Chin Chen
Shahid Hussain

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634758

4,489 views
4 citations

Original Research

Published on 01 Sep 2025

Mechanisms underlying the mitigating action of Maxing Shigan Decoction in acute lung injury caused by influenza virus based on UPLC-HRMS analysis and network pharmacology

in Viral Immunology

Jue Hu
Xiangming Ma
Yufeng Xiao
Chunjing Chen
Chang Liu
Jun Lu
Xiaoqi Wang
Fangguo Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634442

3,270 views

Original Research

Published on 29 Aug 2025

c-Met inhibitor NVP-BVU972 induces antiviral protection and suppresses NF-κB-mediated inflammation

in Viral Immunology

Yunfei Xie
Yang Zhao
Xingyu Chen
Hongli Jia
Xiao Wang
Tianyi Liu
Haocheng Wang
Yang Li
Xuefei Guo
Fuping You

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651730

2,591 views

Original Research

Published on 27 Aug 2025

IFIT3 activation significantly contributes to HIV-1-associated neurodegenerative disorder-mediated neuroinflammation

in Viral Immunology

Ranjit Kumar Das
Nirakar Sahoo
Deepa Roy
Chun Xu
Jose Galarza
Maria Camila Mejia Garza
Hansapani Rodrigo
Asim K. Duttaroy
Upal Roy

Frontiers in Immunology

doi 10.3389/fimmu.2025.1532318

2,961 views

Mini Review

Published on 27 Aug 2025

The role of Tat in HIV latency and reactivation

in Viral Immunology

David M. Margolis
Edward P. Browne

Frontiers in Immunology

doi 10.3389/fimmu.2025.1650385

4,143 views
3 citations

Original Research

Published on 21 Aug 2025

Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD

in Viral Immunology

Muqi Wang
Meng Zhang
Huiling Deng
Yufeng Zhang
Chenrui Liu
Yuan Chen
Chuting Zhang
Wen Zhang
Xiaoli Jia
Shuangsuo Dang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620633

3,011 views
2 citations

Original Research

Published on 21 Aug 2025

Attenuation of IFITM proteins’ antiviral activity through sequestration into intraluminal vesicles of late endosomes

in Viral Immunology

David Prikryl
You Zhang
Smita Verma
Gregory B. Melikyan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647166

2,334 views

Original Research

Published on 20 Aug 2025

The role of the 3′-UTR of the chemokine receptor CCR2 and hnRNPA0 in regulating mRNA stability and subcellular distribution in human CD4+ T cells

in Viral Immunology

Yunus Yukselten
Hanan Wishah
Lingyun Wang
Richard E. Sutton

Frontiers in Immunology

doi 10.3389/fimmu.2025.1655273

3,068 views
1 citation

Correction

Published on 19 Aug 2025

Correction: High-dimensional single-cell phenotyping unveils persistent differences in immune cell profiles between severe and moderate seasonal influenza

in Viral Immunology

Frontiers Production Office

Frontiers in Immunology

doi 10.3389/fimmu.2025.1685215

876 views

2,756 articles

articles

HIV subtype-specific gp140-CD4 binding, Temsavir efficacy, and identification of novel adhesion inhibitors against Chinese HIV strains

Antiviral and immunomodulatory effect of zapnometinib in animal models and hospitalized COVID-19 patients

Impact of pregnant mothers’ previous COVID-19 infection and vaccination on newborns’ serological profiling

HIV and the gut: implications for HIV persistence, immune dysfunction and cure strategies

Host proteases: key regulators in viral infection and therapeutic targeting

Transcriptomic and proteomic profiling reveal immune and metabolic dysregulation in the colonic mucosa of people living with HIV with incomplete immune recovery

Association between human herpesvirus 6 status and sarcopenia risk: a UK biobank cohort study with sex-specific patterns and telomere length modification

Serum matters: human platelet lysate enables physiological modeling of HIV-1 infection in dendritic cells

Immunogenicity and safety of the booster COVID-19 vaccine among people with HIV: a systematic review and meta-analysis

Commentary: Long COVID in pediatric age: an observational, prospective, longitudinal, multicenter study in Italy

HIV-associated depression: a translational framework targeting neuroimmune inflammation and psychosocial stress modulation

Advanced aggressive clinical features may be associated with immune dysfunction in patients with HIV-positive Hodgkin lymphoma in the cART era: a multicenter study from China

Human cytomegalovirus infection-induced lymphocytosis diagnosed by metagenomic next-generation sequencing: a case report and literature review

Co-expression of PD1+ and HLA-DR+ in CD8+ T cells is increased in tonsils of children with EBV primary and persistent infection

Cure of chronic hepatitis C virus infection after DAA treatment only partially restores the functional capacity of exhausted T cell subsets: a systematic review

The emerging role of extracellular vesicles in viral transmission and immune evasion

Mechanisms underlying the mitigating action of Maxing Shigan Decoction in acute lung injury caused by influenza virus based on UPLC-HRMS analysis and network pharmacology

c-Met inhibitor NVP-BVU972 induces antiviral protection and suppresses NF-κB-mediated inflammation

IFIT3 activation significantly contributes to HIV-1-associated neurodegenerative disorder-mediated neuroinflammation

The role of Tat in HIV latency and reactivation

Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD

Attenuation of IFITM proteins’ antiviral activity through sequestration into intraluminal vesicles of late endosomes

The role of the 3′-UTR of the chemokine receptor CCR2 and hnRNPA0 in regulating mRNA stability and subcellular distribution in human CD4+ T cells

Correction: High-dimensional single-cell phenotyping unveils persistent differences in immune cell profiles between severe and moderate seasonal influenza