Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 17 Sep 2025

The role of α-hydroxybutyrate in modulating sepsis progression: identification of key targets and biomarkers through multi-database data mining, machine learning, and unsupervised clustering

in Predictive Toxicology

Qing Lu
Yujie Wu
Dayong Liao
Ying Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1615269

498 views

Editorial

Published on 16 Sep 2025

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, volume III

in Predictive Toxicology

Alex Boye
Yanzhu Zhu
Xinwei Li
Michel Mansur Machado
Fatma M. El Demerdash
Xu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690145

601 views

Original Research

Accepted on 15 Sep 2025

Role of biomarker SOCS1 in peritoneal dialysis-associated peritoneal fibrosis and immune infiltration based on machine learning screening

in Predictive Toxicology

Xin Ma
Xiaona He
Yun Wang
Marcin Grzegorzek
Wenjie Long
Hongxi Chen
Fang Gao
Nan Mao
Xinyu Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646948

193 views

Opinion

Accepted on 11 Sep 2025

Minocycline-induced DRESS: Could Dosage in Relation to Body Fat Mass Be a Contributing Factor?

in Predictive Toxicology

Vincent Descamps

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681474

678 views

Review

Accepted on 10 Sep 2025

The Canonical Wnt Pathway in Osteoporosis: A Scoping Review of Key Compounds and Proteins Modulating Wnt-Induced Osteogenesis

in Predictive Toxicology

Nyruz Elahmer
Sok Kuan Wong
Nur Khadijah Muhamad Jamil
Isa Naina Mohamed
Sabarul Mokhtar
Norliza Muhammad

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669222

771 views

Correction

Published on 09 Sep 2025

Correction: Gastrointestinal stromal tumors with the use of ripretinib and sunitinib: real-world adverse event analysis based on the FDA adverse event reporting system (FAERS)

in Predictive Toxicology

Xinzhen Che
Yong Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689499

1,088 views

Original Research

Published on 03 Sep 2025

Comprehensive safety assessment of Qiwei Tiexie Pill: integrating histopathological, biochemical, and metabolomic analyses in a rat model

in Predictive Toxicology

Qi Zheng
Wenya Liu
Cong Wang
Zhaoben Kan
Qian Wang
Lu Cui
Zhaoxiang Lin
Feng Zhou
Xin Feng
Junsong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567316

1,117 views

Case Report

Published on 02 Sep 2025

Successful rescue of a rare case of refractory shock due to multidrug toxicity: a case report

in Predictive Toxicology

Yuhua Xie
Yujie Zhou
Yunxing Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669831

818 views

Original Research

Published on 29 Aug 2025

Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice

in Predictive Toxicology

Teame Gereziher Mehari
Maorong Jiang
Dandan Gu
Jiaxi Qian
Jungfeng Tang
Ashenafi Kiros Wubshet
Hui Fang
Kai Wang
Deng-Bing Yao
Baohua Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654299

889 views

Case Report

Published on 29 Aug 2025

Aortic dissection induced by licorice tablets overdose: a Case Report

in Predictive Toxicology

Xin Luo
Yuhan Wang
Bin Liu
Duyi Zhang
Yanfen Chai
Lijun Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610147

870 views

Original Research

Published on 26 Aug 2025

Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study

in Predictive Toxicology

Jing Ren
Xinfeng Cai
Wei Ge
Jinlin Guo
Shan Wang
Qinhui Wang
Linna Liu
Le Yang
Qi Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625003

855 views

Case Report

Published on 25 Aug 2025

Case Report: A case of sudden death due to occupational nicotine poisoning: clinical presentation and MRI findings

in Predictive Toxicology

Jianjian Liu
Zhaozhao Shan
Xiangdong Jian
Baotian Kan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567380

1,073 views

Original Research

Published on 21 Aug 2025

Integrated neurobehavioral and organ-specific safety profiling of baicalin: acute/subacute toxicity studies

in Predictive Toxicology

Jiali Yang
Mengyu Chen
Wan Zhang
Jia Liu
Jing Zhao
Xin Ping
Ye Lu
Pei He
Lin Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607919

903 views

Case Report

Published on 20 Aug 2025

Case Report: Rhabdomyolysis following initiation of tirzepatide

in Predictive Toxicology

Jonas Michael Bodanowitz
Isabell Mattes
Micha Loebermann
Carlos Fritzsche

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660785

2,651 views

Original Research

Published on 11 Aug 2025

Viral infections and related fatal adverse events associated with complement inhibitors for PNH: a real-world pharmacovigilance analysis in FAERS

in Predictive Toxicology

Jinman Zhong
Chang Chen
Yunman Xu
Yueping He
Jiewen Tan
Dan Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1639685

1,290 views

Original Research

Published on 08 Aug 2025

Enhancing the confidence of potential targets enriched by similarity-centric models: the crucial role of the similarity threshold

in Predictive Toxicology

Ling-Fei Tong
You-Jin Ge
Su-Qing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574540

614 views