Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 01 Oct 2025

Drug-induced dermatomyositis: a pharmacovigilance study of the FDA adverse event reporting system

in Predictive Toxicology

Jianing Bi
Hanzhang Xie
Yixuan Yang
Qiaochu Chen
Bingnan Cui
Zhanshuo Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526836

2,897 views
1 citation

Original Research

Published on 01 Oct 2025

Role of biomarker SOCS1 in peritoneal dialysis-associated peritoneal fibrosis and immune infiltration based on machine learning screening

in Predictive Toxicology

Xin Ma
Xiaona He
Yun Wang
Marcin Grzegorzek
Wenjie Long
Hongxi Chen
Fang Gao
Nan Mao
Xinyu Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1646948

2,931 views

Opinion

Published on 25 Sep 2025

Minocycline-induced DRESS: could dosage in relation to body fat mass be a contributing factor?

in Predictive Toxicology

Vincent Descamps

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1681474

2,223 views
1 citation

Case Report

Published on 24 Sep 2025

MRI imaging manifestations of severe toxic encephalopathy induced by excessive metoclopramide and multiple drug overdose: a case report

in Predictive Toxicology

Pengfei Liang
Yuncheng Tang
Xiaolin Zhang
Li Zhang
Juan Zhao
Haowen Tang
Zeyu Wu
Qiming Fang
Zhicheng Fang
Zhiwen Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683132

3,368 views
3 citations

Original Research

Published on 17 Sep 2025

The role of α-hydroxybutyrate in modulating sepsis progression: identification of key targets and biomarkers through multi-database data mining, machine learning, and unsupervised clustering

in Predictive Toxicology

Qing Lu
Yujie Wu
Dayong Liao
Ying Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1615269

3,214 views
1 citation

Editorial

Published on 16 Sep 2025

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, volume III

in Predictive Toxicology

Alex Boye
Yanzhu Zhu
Xinwei Li
Michel Mansur Machado
Fatma M. El Demerdash
Xu Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1690145

2,395 views

Correction

Published on 09 Sep 2025

Correction: Gastrointestinal stromal tumors with the use of ripretinib and sunitinib: real-world adverse event analysis based on the FDA adverse event reporting system (FAERS)

in Predictive Toxicology

Xinzhen Che
Yong Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1689499

1,835 views

Original Research

Published on 03 Sep 2025

Comprehensive safety assessment of Qiwei Tiexie Pill: integrating histopathological, biochemical, and metabolomic analyses in a rat model

in Predictive Toxicology

Qi Zheng
Wenya Liu
Cong Wang
Zhaoben Kan
Qian Wang
Lu Cui
Zhaoxiang Lin
Feng Zhou
Xin Feng
Junsong Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567316

2,411 views

Case Report

Published on 02 Sep 2025

Successful rescue of a rare case of refractory shock due to multidrug toxicity: a case report

in Predictive Toxicology

Yuhua Xie
Yujie Zhou
Yunxing Cao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1669831

2,224 views

Case Report

Published on 29 Aug 2025

Aortic dissection induced by licorice tablets overdose: a Case Report

in Predictive Toxicology

Xin Luo
Yuhan Wang
Bin Liu
Duyi Zhang
Yanfen Chai
Lijun Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1610147

2,523 views

Original Research

Published on 29 Aug 2025

Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice

in Predictive Toxicology

Teame Gereziher Mehari
Maorong Jiang
Dandan Gu
Jiaxi Qian
Jungfeng Tang
Ashenafi Kiros Wubshet
Hui Fang
Kai Wang
Deng-Bing Yao
Baohua Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1654299

2,117 views
1 citation

Original Research

Published on 26 Aug 2025

Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study

in Predictive Toxicology

Jing Ren
Xinfeng Cai
Wei Ge
Jinlin Guo
Shan Wang
Qinhui Wang
Linna Liu
Le Yang
Qi Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1625003

2,431 views

Case Report

Published on 25 Aug 2025

Case Report: A case of sudden death due to occupational nicotine poisoning: clinical presentation and MRI findings

in Predictive Toxicology

Jianjian Liu
Zhaozhao Shan
Xiangdong Jian
Baotian Kan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1567380

2,954 views

Original Research

Published on 21 Aug 2025

Integrated neurobehavioral and organ-specific safety profiling of baicalin: acute/subacute toxicity studies

in Predictive Toxicology

Jiali Yang
Mengyu Chen
Wan Zhang
Jia Liu
Jing Zhao
Xin Ping
Ye Lu
Pei He
Lin Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1607919

2,407 views
2 citations

Case Report

Published on 20 Aug 2025

Case Report: Rhabdomyolysis following initiation of tirzepatide

in Predictive Toxicology

Jonas Michael Bodanowitz
Isabell Mattes
Micha Loebermann
Carlos Fritzsche

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660785

5,802 views
2 citations

Original Research

Published on 11 Aug 2025

Viral infections and related fatal adverse events associated with complement inhibitors for PNH: a real-world pharmacovigilance analysis in FAERS

in Predictive Toxicology

Jinman Zhong
Chang Chen
Yunman Xu
Yueping He
Jiewen Tan
Dan Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1639685

3,066 views
1 citation

Original Research

Published on 08 Aug 2025

Enhancing the confidence of potential targets enriched by similarity-centric models: the crucial role of the similarity threshold

in Predictive Toxicology

Ling-Fei Tong
You-Jin Ge
Su-Qing Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574540

1,267 views

Original Research

Published on 06 Aug 2025

Safety assessment of temozolomidee: real-world adverse event analysis from the FAERS database

in Predictive Toxicology

Yu Liu
Lan Ma
Xiaojia Fu
Yi Zhang
Jinyu Zheng
Zhongjun Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1578406

2,789 views
2 citations

Original Research

Published on 01 Aug 2025

Assessment of embryotoxic effects of quinoline yellow using attention-based convolutional neural network and machine learning in zebrafish model

in Predictive Toxicology

Magdalena Majdan
Piotr S. Maciąg
Agata Rogalska

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606214

2,555 views

Original Research

Published on 29 Jul 2025

An occupational pipe leak poisoning

in Predictive Toxicology

Xiangxing Zhang
Tianzi Jian
Mengdi Shi
Chen Wang
Xiangdong Jian
Qilu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1514565

1,631 views

Review

Published on 29 Jul 2025

Assessing biomarkers of exposure to carcinogens associated with combustible cigarettes, electronic cigarettes, and heated tobacco products: a systematic review and meta-analysis

in Predictive Toxicology

Yue Cao
Lin Zhang
Mengqi Yang
Jiaxuan Li
Xi Chen
Fangzhen Zheng
Jianqiang Zhang
Xiao Xu
Xiaona Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1630961

3,991 views
1 citation

Original Research

Published on 25 Jul 2025

Bridging the gaps in detection of structural cardiotoxicity in stem cell-derived cardiomyocytes: promise of miR-133b, miR-184 and miR-208b-3p

in Predictive Toxicology

M. Cherubin
A. Delaunois
J. P. Valentin
M. Alaerts
P. J. Guns
V. Gryshkova

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1584734

1,539 views

Case Report

Published on 23 Jul 2025

Case Report: A case of occupational methyl iodide-induced encephalopathy

in Predictive Toxicology

Hongyu Liu
Ruikai Shang
Qiaoxin Tian
Yuru Liu
Xiangdong Jian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574692

1,205 views
1 citation

Case Report

Published on 21 Jul 2025

Case Report: Infliximab for hydroxychloroquine-induced AGEP with IL17A and IL36RN mutations: a case report and management considerations

in Predictive Toxicology

Xiaoyun Jiang
Chunting Hua
Chenxi Feng
Hao Cheng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580170

1,762 views
1 citation

495 articles

articles

Drug-induced dermatomyositis: a pharmacovigilance study of the FDA adverse event reporting system

Role of biomarker SOCS1 in peritoneal dialysis-associated peritoneal fibrosis and immune infiltration based on machine learning screening

Minocycline-induced DRESS: could dosage in relation to body fat mass be a contributing factor?

MRI imaging manifestations of severe toxic encephalopathy induced by excessive metoclopramide and multiple drug overdose: a case report

The role of α-hydroxybutyrate in modulating sepsis progression: identification of key targets and biomarkers through multi-database data mining, machine learning, and unsupervised clustering

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, volume III

Correction: Gastrointestinal stromal tumors with the use of ripretinib and sunitinib: real-world adverse event analysis based on the FDA adverse event reporting system (FAERS)

Comprehensive safety assessment of Qiwei Tiexie Pill: integrating histopathological, biochemical, and metabolomic analyses in a rat model

Successful rescue of a rare case of refractory shock due to multidrug toxicity: a case report

Aortic dissection induced by licorice tablets overdose: a Case Report

Histopathological examination and transcriptomic profiling reveal gossypol toxicity-responsive genes related to fertility in mice

Risk factors for voriconazole-associated hepatotoxicity in patients with liver dysfunction: a retrospective nested case–control study

Case Report: A case of sudden death due to occupational nicotine poisoning: clinical presentation and MRI findings

Integrated neurobehavioral and organ-specific safety profiling of baicalin: acute/subacute toxicity studies

Case Report: Rhabdomyolysis following initiation of tirzepatide

Viral infections and related fatal adverse events associated with complement inhibitors for PNH: a real-world pharmacovigilance analysis in FAERS

Enhancing the confidence of potential targets enriched by similarity-centric models: the crucial role of the similarity threshold

Safety assessment of temozolomidee: real-world adverse event analysis from the FAERS database

Assessment of embryotoxic effects of quinoline yellow using attention-based convolutional neural network and machine learning in zebrafish model

An occupational pipe leak poisoning

Assessing biomarkers of exposure to carcinogens associated with combustible cigarettes, electronic cigarettes, and heated tobacco products: a systematic review and meta-analysis

Bridging the gaps in detection of structural cardiotoxicity in stem cell-derived cardiomyocytes: promise of miR-133b, miR-184 and miR-208b-3p

Case Report: A case of occupational methyl iodide-induced encephalopathy

Case Report: Infliximab for hydroxychloroquine-induced AGEP with IL17A and IL36RN mutations: a case report and management considerations