REVIEW article
Front. Plant Sci.
Sec. Plant Cell Biology
Plant-Derived Vesicles: Isolation Strategies and Therapeutic Applications
Provisionally accepted
- 1Shandong Technician Institute, Jinan, China
- 2Shandong University of Traditional Chinese Medicine, Jinan, China
- 3Jinan Third People's Hospital, Jinan, China
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Plant-derived vesicles (PDVs) are vesicle-like structures secreted by plant cells, containing components such as membrane proteins、nucleic acids and enzymes. These vesicles play significant roles in plant growth, tissue repair and self-defense. Additionally, PDVs are safe and easy to extract, and they demonstrate promising therapeutic effects on inflammation, cancer and wound healing. Due to their unique properties, PDVs can serve as drug carriers, effectively shuttling through cells to aid disease treatment. In this study, we review the methods for separating and preparing PDVs and highlight their application in disease treatment using nanovesicles derived from plants such as cucumber、broccoli、 lemon、turmeric、ginseng、ginger、garlic、grape、yam、tomato and grapefruit. The biomedical applications of PDVs in drug delivery, anticancer therapies, anti-inflammatory responses, antioxidation and wound healing are also introduced. Finally, the feasibility, characteristics, challenges and future prospects of PDVs are discussed.
Keywords: Drug delivery, Nanovesicles, Plant-derived vesicles, preparation and purification of PDVs, Therapeutic applications
Received: 06 Jul 2025; Accepted: 09 Dec 2025.
Copyright: © 2025 Li, Wang, Wang, Du and Pang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaogang Pang
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.