ORIGINAL RESEARCH article
Front. Plant Sci.
Sec. Plant Pathogen Interactions
This article is part of the Research TopicDecoding Receptor-Mediated Recognition: Comparative Study of PRR and NLR Functions in Host Resistance to Plant PathogensView all articles
The Vitis vinifera receptor VvLYK6 negatively regulates chitin-triggered immune responses and promotes fungal infections
Provisionally accepted
Jérémy Villette1
Tania Marzari1David Landry2Thibault Roudaire1Agnès Klinguer1Nathalie Leborgne-Castel1Céline Vicedo2Virginie Gasciolli2Cécile Pouzet3
Benoît Lefebvre2
Marie-claire Heloir1
Benoit Poinssot1*- 1UMR Agroécologie, Université Bourgogne Europe, INRAE, Institut Agro, Dijon, France
- 2Laboratoire des interactions plantes microbes environnement, Castanet-Tolosan, France
- 3Federation de Recherche Agrobiosciences Interactions et Biodiversite, Castanet-Tolosan, France
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Abstract Botrytis cinerea is recognized as one of the most damaging fungal pathogens affecting grapevine (Vitis vinifera), directly impacting both grape yield and wine quality. Identifying new genes involved in the interaction between V. vinifera and B. cinerea appears to be a promising strategy for enhancing grapevine resistance in future breeding programs. During pathogen infection, plasma membrane-localized pattern recognition receptors (PRRs) are responsible for detecting conserved microbe-associated molecular patterns (MAMPs). Among PRRs, members of the LysM receptor-like kinase family are well known to mediate the recognition of fungal MAMPs and triggering plant immune signaling pathways. Interestingly, a novel member of this receptor family, named VvLYK6, was identified in grapevine as the most highly upregulated during B. cinerea infection. To investigate the role of VvLYK6 in plant immunity, we conducted overexpression studies in Arabidopsis thaliana and grapevine cell suspensions. Overexpression of VvLYK6 led to a reduction in chitin-induced MAPK activation, decreased expression of defense-related genes, reduced callose deposition, and increased plant susceptibility to fungal pathogens in A. thaliana. Based on these findings, we conclude that VvLYK6 acts as a negatively regulator of chitin-triggered immune responses, suggesting its potential role as a susceptibility gene during fungal infections.
Keywords: Vitis vinifera, MAMP, Chitin hexamer, inhibition, Plant Immunity, Fungal pathogens
Received: 15 Sep 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Villette, Marzari, Landry, Roudaire, Klinguer, Leborgne-Castel, Vicedo, Gasciolli, Pouzet, Lefebvre, Heloir and Poinssot. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Benoit Poinssot, benoit.poinssot@u-bourgogne.fr
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.