Frontiers in Oncology | Cancer Genetics

Original Research

Published on 02 Sep 2025

Integrated single-cell and bulk RNA-seq analysis reveals prognostic stemness genes in leiomyosarcoma

in Cancer Genetics

Aiju Lou
Yu Cai
Tuquan Zheng
Long Zhang
Yupeng Hu
Huachi Li
Lang Ying

Frontiers in Oncology

doi 10.3389/fonc.2025.1604413

2,901 views
1 citation

Original Research

Published on 01 Sep 2025

Combination of BRCA deep targeted sequencing and shallow whole genome sequencing to detect homologous recombination deficiency in ovarian cancer

in Cancer Genetics

Thien-Phuc Nguyen Hoang
Nam H. B. Tran
Tien Anh Nguyen
My T. T. Ngo
Anh Duong Doan
Du Quyen Nguyen
Hung Sang Tang
Duy Sinh Nguyen
Cam Tu Nguyen Thi
Thanh Thuy Do Thi

Frontiers in Oncology

doi 10.3389/fonc.2025.1593881

2,891 views
1 citation

Review

Published on 01 Sep 2025

Interactions between ALKBH5 and reader proteins in tumors: functions and molecular mechanisms

in Cancer Genetics

Jiahui Ou
Bingchen Liu
Yi Yu
Yingchun He
Yuyu Gao
Lingli Chen
Xia Chen
Huai Tao

Frontiers in Oncology

doi 10.3389/fonc.2025.1611007

2,028 views

Review

Published on 27 Aug 2025

POLE-mutated endometrial cancer: new perspectives on the horizon?

in Cancer Genetics

Daniele Fanale
Lidia Rita Corsini
Paola Piraino
Erika Pedone
Chiara Brando
Tancredi Didier Bazan Russo
Pietro Ferraro
Alisia Simone
Silvia Contino
Ornella Prestifilippo

Frontiers in Oncology

doi 10.3389/fonc.2025.1633260

4,826 views
1 citation

Original Research

Published on 27 Aug 2025

Integration of single-cell and bulk RNA sequencing to identify unique tumor stem cells and construct novel prognostic markers for assessing ESCA prognosis and drug sensitivity

in Cancer Genetics

Jia Shi
Danni Qiao
Qiongyang Lv
Yaliang Fan
Haibin Yu
Guiming Hu
Longhao Wang
Beibei Sha

Frontiers in Oncology

doi 10.3389/fonc.2025.1649877

2,247 views

Original Research

Published on 22 Aug 2025

Application of low-coverage whole-genome sequencing technology in risk stratification of colorectal adenomas

in Cancer Genetics

Guo Zhili
Xue Yuyue
Yu Fang
Ren Dianqun
Zhang Qin
Liu Jie

Frontiers in Oncology

doi 10.3389/fonc.2025.1591548

1,608 views

Original Research

Published on 22 Aug 2025

Role of Meox1 in promoting lung tumor vascularization and impairing CD8+ T cell mediated immunity

in Cancer Genetics

Dacheng Yang
Qian Li
Zisheng Chen
Wei Kevin Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1645671

1,968 views

Review

Published on 19 Aug 2025

From trash to treasure: tumor draining lymph nodes as a multi-omics goldmine in cancer therapy

in Cancer Genetics

Yina Li
Zihan Chen
Zhikun Guo
Jiangnan Yu
Jianan Lu
Lei Wang
Qian Zhou

Frontiers in Oncology

doi 10.3389/fonc.2025.1636942

3,113 views

Case Report

Published on 18 Aug 2025

Case Report: Multi-cancer early detection utilizing blood-based genomics: Single-institution case series of novel cancer screening

in Cancer Genetics

Somya Khare
Jason C. Burton
Francis De Asis
Saron Mekonnen
Mason J. Stewart-McLellan
Diana Potts
Tiffani L. Howard
Nima Nabavizadeh

Frontiers in Oncology

doi 10.3389/fonc.2025.1637999

2,625 views
1 citation

Original Research

Published on 11 Aug 2025

TCR and BCR repertoire analysis reveals distinct signatures between benign and malignant ovarian tumors

in Cancer Genetics

Zhonghuang Wang
Zhe Zhang
Dongli Zhao
Zhenglin Du
Bixia Tang
Enhui Jin
Hailong Kang
Wenming Zhao
Yuanguang Meng

Frontiers in Oncology

doi 10.3389/fonc.2025.1630707

2,057 views
1 citation

Original Research

Published on 11 Aug 2025

To explore the prognostic efficacy and mechanism of ABCC5 clinical scoring model in hepatocellular carcinoma

in Cancer Genetics

Yu Deng
Ning Yang
Chengyu Huang
Meiting Long
Junming Wu
Ke Mo
Zijun Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1519533

1,778 views

Review

Published on 08 Aug 2025

CHAC1 in urological tumors: contextual dualism and therapeutic implications

in Cancer Genetics

Deyu Wang
Yongquan Wan
Yunxiang Li
Yuan Ren
Jiakai Ma
Si Ge
Ziqiang Zeng
Zuoping Wang
Lei Zhen

Frontiers in Oncology

doi 10.3389/fonc.2025.1610915

2,861 views

Original Research

Published on 01 Aug 2025

Genetic characterization of Lynch syndrome germline variants in a LATAM cohort using a customized NGS gene panel

in Cancer Genetics

Cecilia Mathó
Santiago Chávez
Rafael Sebastián Fort
Adriana Della Valle
Florencia Neffa
José Roberto Sotelo-Silveira
Nora Artagaveytia
María Ana Duhagon

Frontiers in Oncology

doi 10.3389/fonc.2025.1589765

2,921 views

Original Research

Published on 29 Jul 2025

RNLS promotes ovarian cancer growth and inhibits ferroptosis via mediating STAT3

in Cancer Genetics

Liang Lin
Zuolian Xie
Peilin Zhong
Jian Chen
Ning Ma
Ling Li
An Lin
Li Chen

Frontiers in Oncology

doi 10.3389/fonc.2025.1604377

1,925 views

Review

Published on 24 Jul 2025

Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina women

in Cancer Genetics

Laura Rey-Vargas
Lina María Bejarano-Rivera
Patricia López-Correa
Diego Felipe Ballen-Lozano
Silvia J. Serrano-Gómez

Frontiers in Oncology

doi 10.3389/fonc.2025.1635681

2,147 views
1 citation

Review

Published on 17 Jul 2025

The prognostic and predictive value of peripheral immune-related proteins in patients with lung cancer treated with radiotherapy

in Cancer Genetics

Shaowen Lyu
Rianne D. W. Vaes
Iris E. W. G. Laven
Francesco Cortiula
Lizza E. L. Hendriks
Marc A. Vooijs
Dirk K. M. De Ruysscher

Frontiers in Oncology

doi 10.3389/fonc.2025.1625212

2,525 views

Original Research

Published on 09 Jul 2025

TLR4/MyD88 expression patterns and novel genetic variants: association with aggressive clinicopathological features in colorectal cancer

in Cancer Genetics

Thai Tra Dang
Viet Nhat Pham
Ngoc Dung Tran
Thu Hang Ngo
Van Mao Can
Huy Hoang Nguyen
Thi Xuan Nguyen
Thanh Chung Dang

Frontiers in Oncology

doi 10.3389/fonc.2025.1568729

2,033 views
1 citation

Original Research

Published on 01 Jul 2025

SPP1+ tumor-associated macrophages define a high-risk subgroup and inform personalized therapy in hepatocellular carcinoma

in Cancer Genetics

Wei-Xuan Xu
Ya-Mei Ye
Jia-Lin Chen
Xin-Ying Guo
Chen Li
Juan Luo
Lin-Bin Lu
Xiong Chen

Frontiers in Oncology

doi 10.3389/fonc.2025.1606195

4,282 views
3 citations

Original Research

Published on 18 Jun 2025

Deciphering the impact of intra-tumoral bacterial infiltration on multi-omics profiles in low-grade gliomas

in Cancer Genetics

Wenshu Li
Zixiang Zhu
Longyuan Li
Xin Wu
Jiaxuan Li
Yi Zhou
Lingwen Gu
Pranathi Vittal
Zhouqing Chen
Zhong Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1582068

1,985 views
1 citation

Perspective

Published on 09 Jun 2025

Personalized preventive medicine using genomic information: future perspective and corresponding research plan

in Cancer Genetics

Hiroto Narimatsu
Kaname Watanabe
Ann Sato
Eri Haneda
Masumi Okamoto
Haruka Nakada
Sho Nakamura

Frontiers in Oncology

doi 10.3389/fonc.2025.1599753

2,133 views

Case Report

Published on 06 Jun 2025

Primary pancreas NTRK-rearranged neoplasm harboring an EVT6::NTRK3 fusion with a sclerosing epithelioid fibrosarcoma morphology: a case report and comprehensive review of the literature

in Cancer Genetics

Xin Wu
Dujuan Li
Fangfang Fu
Lifei Lian

Frontiers in Oncology

doi 10.3389/fonc.2025.1526281

2,907 views

Original Research

Published on 05 Jun 2025

EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming

in Cancer Genetics

Bo Guan
Cong Huang
Jun He
Weimin Shan
Di Cui
Xiaowei Li
Chaozhao Liang
Zongyao Hao

Frontiers in Oncology

doi 10.3389/fonc.2025.1541429

2,717 views
2 citations

Review

Published on 04 Jun 2025

The role of MYEOV gene: a review and future directions

in Cancer Genetics

Yidan Xi
Xuefei Liu
Yanan Ge
Mingzhe Jiang
Dong Zhao
Ershu Zhao
Fei Cai
Xinlong Wang
Jiatong Li
Tingting Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1543590

2,321 views
1 citation

Review

Published on 02 Jun 2025

The regulatory network of epithelial-mesenchymal transition-associated non-coding RNAs in thyroid cancer: molecular mechanisms, clinical implications, and therapeutic strategies

in Cancer Genetics

Rui Zhao
Jiaju Tian
Jing Peng
Ruiting Ma
Songbo Fu

Frontiers in Oncology

doi 10.3389/fonc.2025.1592467

2,476 views
2 citations

1,233 articles

articles

Integrated single-cell and bulk RNA-seq analysis reveals prognostic stemness genes in leiomyosarcoma

Combination of BRCA deep targeted sequencing and shallow whole genome sequencing to detect homologous recombination deficiency in ovarian cancer

Interactions between ALKBH5 and reader proteins in tumors: functions and molecular mechanisms

POLE-mutated endometrial cancer: new perspectives on the horizon?

Integration of single-cell and bulk RNA sequencing to identify unique tumor stem cells and construct novel prognostic markers for assessing ESCA prognosis and drug sensitivity

Application of low-coverage whole-genome sequencing technology in risk stratification of colorectal adenomas

Role of Meox1 in promoting lung tumor vascularization and impairing CD8+ T cell mediated immunity

From trash to treasure: tumor draining lymph nodes as a multi-omics goldmine in cancer therapy

Case Report: Multi-cancer early detection utilizing blood-based genomics: Single-institution case series of novel cancer screening

TCR and BCR repertoire analysis reveals distinct signatures between benign and malignant ovarian tumors

To explore the prognostic efficacy and mechanism of ABCC5 clinical scoring model in hepatocellular carcinoma

CHAC1 in urological tumors: contextual dualism and therapeutic implications

Genetic characterization of Lynch syndrome germline variants in a LATAM cohort using a customized NGS gene panel

RNLS promotes ovarian cancer growth and inhibits ferroptosis via mediating STAT3

Differences in the distribution of HER2-positive breast tumors according to ethnicity and genetic variants in ERBB2: a special focus on Asian and Latina women

The prognostic and predictive value of peripheral immune-related proteins in patients with lung cancer treated with radiotherapy

TLR4/MyD88 expression patterns and novel genetic variants: association with aggressive clinicopathological features in colorectal cancer

SPP1+ tumor-associated macrophages define a high-risk subgroup and inform personalized therapy in hepatocellular carcinoma

Deciphering the impact of intra-tumoral bacterial infiltration on multi-omics profiles in low-grade gliomas

Personalized preventive medicine using genomic information: future perspective and corresponding research plan

Primary pancreas NTRK-rearranged neoplasm harboring an EVT6::NTRK3 fusion with a sclerosing epithelioid fibrosarcoma morphology: a case report and comprehensive review of the literature

EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming

The role of MYEOV gene: a review and future directions

The regulatory network of epithelial-mesenchymal transition-associated non-coding RNAs in thyroid cancer: molecular mechanisms, clinical implications, and therapeutic strategies