Frontiers in Toxicology

Review

Published on 02 Dec 2025

Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review

in In Vitro Toxicology

Niraj Chaudhary
Luis G. Villa-Diaz

Frontiers in Toxicology

doi 10.3389/ftox.2025.1667573

1,788 views

Original Research

Accepted on 30 Nov 2025

Evaluating chemotherapy-driven placental alterations and their impact on fetal development

in Developmental and Reproductive Toxicology

Katrien De Clercq
Carolina Velazquez
Eleonora Persoons
Vera Elena Renée Annechien Wolters
Marieke van de Ven
Ji-Ying Song
Frédéric Amant

Frontiers in Toxicology

345 views

Original Research

Published on 27 Nov 2025

Unseen contaminants in Portuguese reservoirs: linking microplastics to ecological potential and human pressures

in Environmental Toxicology

C. Guimarães
I. Pinto
J. A. Padilha
S. C. Antunes

Frontiers in Toxicology

doi 10.3389/ftox.2025.1705228

1,085 views

Original Research

Published on 27 Nov 2025

Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

in Developmental and Reproductive Toxicology

Hubert Dirven
Aleksandra Bogusz
Hans Bouwmeester
Mathias Busch
Guillaume Duflos
Gunnar S. Eriksen
Margarida Fardilha
Daniela Flores-Gomez
Nina Franko
Laurent Gaté

Frontiers in Toxicology

doi 10.3389/ftox.2025.1719035

2,189 views

Original Research

Published on 26 Nov 2025

AlCl3 exposure induces nephrotoxicity in mice by mediating ferroptosis through the NRF2 signaling pathway

in Environmental Toxicology

Liu-Dan Liang
Xiao-Yue Zhao
Li Li
Sheng Liang
Jin-Min Zhang
Jian-Nan Lv
Feng-Lian Deng
Chun-Lei Lu
Qian Li
Qi-Wen Huang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1692410

1,244 views

Original Research

Published on 24 Nov 2025

Cadmium and glyphosate jointly compromise sperm function, fertilization, and early development in Prochilodus magdalenae

in Developmental and Reproductive Toxicology

Jose Espinosa-Araujo
Lucellys Sierra-Marquez
Victor Atencio-Garcia
Jesus Olivero-Verbel

Frontiers in Toxicology

doi 10.3389/ftox.2025.1698489

1,057 views

Systematic Review

Published on 24 Nov 2025

Endocrine disruption rewards: bisphenol-A-induced reproductive toxicity and the precision ameliorative potential of flavonoids in preclinical studies. A systematic review and meta-analysis

in Developmental and Reproductive Toxicology

Michael Ben Okon
Ilemobayo Victor Fasongbon
Dominic Swase
Reuben Samson Dangana
Wusa Makena
Vivian Onyinye Ojiakor
Ekom Monday Etukudo
Joan Chebet
Angela Mumbua Musyoka
Sandra Etumah Ifie

Frontiers in Toxicology

doi 10.3389/ftox.2025.1687862

1,724 views

Original Research

Published on 20 Nov 2025

Nose-to-brain translocation of inhaled ultrafine elongated particles: facts and mysteries

in Neurotoxicology

U. M. Graham
J. M. Pinto
J. Weuve
A. K. Dozier
R. Rogers
S. Nag
J. Schneider
J. D. Kaufman
D. A. Bennett
G. Oberdörster

Frontiers in Toxicology

doi 10.3389/ftox.2025.1655149

2,306 views
4 citations

Review

Published on 20 Nov 2025

Overall effects of microplastics on brain

in Environmental Toxicology

Su-jun Fang
Zhao-di Yin
Li-fan Li
Qi Cai
Peng-fei Zheng
Li-zhen Chen

Frontiers in Toxicology

doi 10.3389/ftox.2025.1619096

3,839 views
1 citation

Original Research

Published on 20 Nov 2025

A new type of ultrasonic water alleviates constipation with favorable safety

in Food and Nutritional Toxicology

Jiarong Hu
Xinyi Hu
Wenjie Huang
Fen Wang
Zhongqi Xia
Chenyang Zhu
Junwei Chow
Shiwei Yan
Longzhou Li
Haiyang Liu

Frontiers in Toxicology

doi 10.3389/ftox.2025.1679872

1,060 views

Original Research

Published on 19 Nov 2025

Decoding PFAS immunotoxicity: a NAMs-based comparison of short vs. long chains

in Environmental Toxicology

Martina Iulini
Valentina Galbiati
Marina Marinovich
Emanuela Corsini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1665163

1,903 views
2 citations

Systematic Review

Published on 19 Nov 2025

Systematic literature review and meta-analysis on the reproductive effects of micro- pollutants in humans and animals

in Developmental and Reproductive Toxicology

Luca Coppeta
Cristiana Ferrari
Lorenzo Ippoliti
Luisa Campagnolo
Andrea Magrini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1671098

1,524 views

Original Research

Published on 17 Nov 2025

Toxicity effects of cadmium and β-cypermethrin on zebrafish by single and combined exposure: oxidative stress and histopathological evaluation

in Environmental Toxicology

Xinkun Fu
Suxian Yang
Yi Zhang
Kai Luo
Yonglin Sun
Yuqi Li

Frontiers in Toxicology

doi 10.3389/ftox.2025.1674140

1,167 views

Case Report

Published on 14 Nov 2025

Medium cut-off membrane expanded hemodialysis for Lithium removal: a case report

in Clinical Toxicology

Katia M. Pérez del Valle
María Moran Magro
Daniel Gaitán Tocora
Nerea Begoña Boldoba
Carmen Benito Puncel
Alberto Silva Obregón
José R. Rodríguez Palomares
Gabriel de Arriba de la Fuente

Frontiers in Toxicology

doi 10.3389/ftox.2025.1677299

1,314 views
2 citations

Opinion

Published on 14 Nov 2025

Revisiting 3Rs: rethinking replacement and new approach methodologies

in In Vitro Toxicology

Jessica Rosolowski
Tilo Weber
Atena Malakpour-Permlid
Stina Oredsson

Frontiers in Toxicology

doi 10.3389/ftox.2025.1664209

1,514 views
1 citation

Original Research

Published on 13 Nov 2025

Biological analysis of Sonchus oleraceus (Linn) extract and its effect on mitigating sodium benzoate-induced cytotoxicity and genotoxicity

in Food and Nutritional Toxicology

Maryam Abdulmalik Althubyani
Abdulmajeed F. Alrefaei
Sameer Hasan Qari
Rayan S. Alharbi
Aljawharah Alqathama

Frontiers in Toxicology

doi 10.3389/ftox.2025.1674822

1,715 views

Original Research

Published on 11 Nov 2025

Toxicological assessment of Chlorella vulgaris and its potential preventive effect in a chronic obstructive pulmonary disease (COPD) mouse model

in Food and Nutritional Toxicology

Lucia Giambastiani
Sofia Fiorentino
Kylie Brady
Andrea Raffaelli
Emilia Bramanti
Erna Cecilia Lorenzini
Vincenzo Longo
Francesca Sparvoli
Luisa Pozzo
Andrea Vornoli

Frontiers in Toxicology

doi 10.3389/ftox.2025.1654583

1,635 views

Editorial

Published on 07 Nov 2025

Editorial: Magnetic resonance imaging contrast agents: the safety of gadolinium

in Clinical Toxicology

John Sy
Joshua DeAguero
Brent Wagner

Frontiers in Toxicology

doi 10.3389/ftox.2025.1664840

3,848 views

Original Research

Published on 06 Nov 2025

Diagnostic value of GPX4, IL-13, periostin, and thiol/disulfide balance in adult patients with scorpion envenomation: a prospective observational study

in Clinical Toxicology

Hasan Buyukaslan
Şenay Koçakoğlu

Frontiers in Toxicology

doi 10.3389/ftox.2025.1697677

934 views

Original Research

Published on 05 Nov 2025

Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds

in Regulatory Toxicology

R. R. Sillito
J. Sutherland
A. Milne
C. Giuliano
C. Sigfridsson
M. Rolf
A. K. Cherian
M. McClafferty
E. I. Rossman
G. Teuns

Frontiers in Toxicology

doi 10.3389/ftox.2025.1655330

3,086 views

Original Research

Published on 05 Nov 2025

Exposure to the herbicide glyphosate leads to inappropriate threat responses and alters gut microbial composition

in Neurotoxicology

Mauricio Cáceres-Chacón
Osmarie Martínez-Guzmán
Héctor A. Haddock-Martínez
Alexdiel Figueroa-Pérez
Sian Rodríguez-Rosado
Jaleniz Suárez-Pérez
Raúl Y. Ramos-Sánchez
Filipa Godoy-Vitorino
Demetrio Sierra-Mercado

Frontiers in Toxicology

doi 10.3389/ftox.2025.1704231

2,270 views

Original Research

Published on 03 Nov 2025

Comprehensive methodology for standardized ecotoxicological assessment of TiO2-based sunscreen leachates in aquatic environment

in Environmental Toxicology

Roberta Nugnes
Giulia De Negri Atanasio
Elisabetta Perata
Erica Lertora
Lorenzo Dondero
Federica Robino
Francesca Tardanico
Cristina Capelli
Fabio Ghioni
Tania Cai

Frontiers in Toxicology

doi 10.3389/ftox.2025.1686954

1,534 views

Original Research

Published on 30 Oct 2025

Montmorillonite-based essential oil carrier and its effects on non-target species: an environmental perspective on its risk assessment

in Environmental Toxicology

Sofia Machado
Catarina Ganilho
Tatiana Andreani
Rose Marie O. F. Sousa
Artur Ribeiro
Ruth Pereira

Frontiers in Toxicology

doi 10.3389/ftox.2025.1696913

1,096 views
1 citation

Review

Published on 30 Oct 2025

Developing an approach for evaluating the cardiotoxic potential of botanicals

in In Vitro Toxicology

Julie Krzykwa
Hemantkumar S. Chaudhari
Andre Monteiro Da Rocha
Matthias Gossmann
Peter Hoffmann
Yaser Khokhar
Nathan Meyer
Jin-Young K. Park
Robert Sprando
Ravi Vaidyanathan

Frontiers in Toxicology

doi 10.3389/ftox.2025.1646044

2,565 views
1 citation