Frontiers in Chemistry | Chemical Biology

Original Research

Published on 04 Sep 2025

K739 is preferentially targeted over K725 in the deSUMOylation process of neuronal nitric oxide synthase

in Chemical Biology

Yuxin Xu
Wei Wan
Nan Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1672437

638 views

Original Research

Published on 01 Sep 2025

Platinum-group metal half-sandwich complexes of 1-(α-d-glucopyranosyl)-4-hetaryl-1,2,3-triazoles: synthesis, solution equilibrium studies, and investigation of their anticancer and antimicrobial activities

in Chemical Biology

Alshimaa I. Zaki
Adrienn Sipos
István Kacsir
Nóra Ildikó Kovács
Éva Kerekes
Evelin Szoták
Csongor Freytag
Máté Demény
István Révész
Péter Buglyó

Frontiers in Chemistry

doi 10.3389/fchem.2025.1619991

1,002 views

Original Research

Published on 29 Aug 2025

Synthesis of oligo-α-(1→2)-4,6-dideoxy-4-formamido-d-mannopyranosides related to the A epitope of the Brucella O-polysaccharide and their use for assaying of serum immunoglobulins

in Chemical Biology

Timur M. Volkov
Yury E. Tsvetkov
Dmitry V. Yashunsky
Anton N. Kuznetsov
Oleg D. Sclyarov
Olesia V. Babicheva
Dmitry O. Zherdev
Liliya I. Mukhametova
Sergei A. Eremin
Vadim B. Krylov

Frontiers in Chemistry

doi 10.3389/fchem.2025.1662885

956 views

Original Research

Published on 21 Aug 2025

A fluorescent probe with a vanillin–pyridine–imidazole core structure for carboxylesterase detection in macrophage polarization during bone homeostasis

in Chemical Biology

Hailong Xia
Xianghe Wang
Weichun Huang
Xindong Jiang
Xionggao Han
Chaoyue Wang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1666238

1,016 views

Review

Published on 16 Jul 2025

Electron transport across the cell envelope via multiheme c-type cytochromes in Geobacter sulfurreducens

in Chemical Biology

Media Zakizadeh Tabari
Allon I. Hochbaum

Frontiers in Chemistry

doi 10.3389/fchem.2025.1621274

1,681 views

Original Research

Published on 24 Jun 2025

Rational design of a NIR fluorescent probe for highly selective sensing of NAD(P)H quinone oxidoreductase 1 in living systems

in Chemical Biology

Fangyu Yang
Li Zhu
Fei Yan
Houli Zhang
Guobiao Liang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1626741

1,252 views

Original Research

Published on 11 Jun 2025

Molecular functional mechanisms of two alcohol acetyltransferases in Lavandula x intermedia (lavandin)

in Chemical Biology

Dafeng Liu
Yanyan Du
Ablikim Abdiriyim
Lvxia Zhang
Daoqi Song
Huashui Deng
Xiongying Wen
Yanyan Zhang
Bingwang Sun

Frontiers in Chemistry

doi 10.3389/fchem.2025.1627286

1,266 views
4 citations

Review

Published on 11 Jun 2025

The role of intrinsically disordered regions of SARS-CoV-2 nucleocapsid and non-structural protein 1 proteins

in Chemical Biology

Getasew Shitaye
Nataliia Ventserova
Gianluca D’Abrosca
Martina Dragone
Eunice Wairimu Maina
Roberto Fattorusso
Rosa Iacovino
Luigi Russo
Carla Isernia
Gaetano Malgieri

Frontiers in Chemistry

doi 10.3389/fchem.2025.1597656

2,134 views
1 citation

Original Research

Published on 27 May 2025

Functional and structural insights into the multicopper oxidase MmcO from Mycobacterium tuberculosis: implications for drug targeting

in Chemical Biology

Dafeng Liu
Feng Yu
Yihan Luo
Ayitunihe Hanate

Frontiers in Chemistry

doi 10.3389/fchem.2025.1565715

1,505 views
1 citation

Original Research

Published on 04 Apr 2025

Asialoglycoprotein receptor-targeted perfluorooctylbromide as a targeted contrast agent for evaluating the severity of carbon tetrachloride-induced acute liver damage in rats

in Chemical Biology

Jinhong Yu
Chaofeng Yang
Pengwei Zhang
Min Wei
Yang Li

Frontiers in Chemistry

doi 10.3389/fchem.2025.1475026

1,272 views

Original Research

Published on 02 Apr 2025

Heme and iron limitation in a GI-tract foundation species leads to a reshuffling of the metalloproteome and a shift toward manganese usage

in Chemical Biology

Ronivaldo Rodrigues da Silva
James Larson
Brian Bothner
Jennifer L. DuBois

Frontiers in Chemistry

doi 10.3389/fchem.2025.1562189

1,323 views
1 citation

Review

Published on 14 Mar 2025

Advances in the structural characterization and pharmacological activity of Salvia miltiorrhiza polysaccharides

in Chemical Biology

Ke Yang
Yi-Jun Liu
Jia-Ning Zhang
Ya-Jing Chen
Jian Yang
Jun-Ping Xiao
Han-Bin Lin
Hong-Jun Yang

Frontiers in Chemistry

doi 10.3389/fchem.2025.1492533

2,127 views
2 citations

Editorial

Published on 07 Mar 2025

Editorial: The influence of metal ions and their complexes on the function and structure of biological macromolecules

in Chemical Biology

Miroslaw Gilski
Mannar R. Maurya
Boguslaw Nocek
Krzysztof Brzezinski

Frontiers in Chemistry

doi 10.3389/fchem.2025.1563537

1,183 views

Review

Published on 03 Mar 2025

Comparative analysis of extraction technologies for plant extracts and absolutes

in Chemical Biology

Shoutao Cao
Jinchang Liang
Mingguang Chen
Chao Xu
Xiaoqiang Wang
Lei Qiu
Xianyan Zhao
Wenxiao Hu

Frontiers in Chemistry

doi 10.3389/fchem.2025.1536590

6,989 views
9 citations

Review

Published on 25 Feb 2025

Major heme proteins hemoglobin and myoglobin with respect to their roles in oxidative stress – a brief review

in Chemical Biology

Rajarshi Sil
Abhay Sankar Chakraborti

Frontiers in Chemistry

doi 10.3389/fchem.2025.1543455

2,965 views
3 citations

Original Research

Published on 24 Jan 2025

Ferula communis leaf extract: antioxidant capacity, UHPLC–MS/MS analysis, and in vivo and in silico toxicity investigations

in Chemical Biology

Imad Ed-Dahmani
Mohamed El Fadili
Ghizlane Nouioura
Fahd Kandsi
Yassine El Atki
Hatem A. Abuelizz
Raffaele Conte
Fatima Zahra Lafdil
Abdeslam Taleb
Abdelfattah Abdellaoui

Frontiers in Chemistry

doi 10.3389/fchem.2024.1485463

2,202 views
3 citations