Frontiers in Toxicology

Original Research

Published on 12 Jan 2026

Role of bisphenol A in the aberrant activation of ionotropic glutamate transporters in the cerebral cortex and altered behavioral responses in C57BL/6J mice

in Neurotoxicology

Jasim Khan
Mohammad Waseem
Kajal Kamble
Suhel Parvez
Basu Dev Banerjee
Sarika Gupta
Sheikh Raisuddin

Frontiers in Toxicology

doi 10.3389/ftox.2025.1680589

735 views

Review

Published on 12 Jan 2026

Food contaminants: mechanisms of toxicity, computational assessment, and mitigation

in Computational Toxicology and Informatics

Laura Escorihuela
Rajesh Kumar Pathak
Benjamí Martorell
Vikas Kumar

Frontiers in Toxicology

doi 10.3389/ftox.2025.1719447

1,347 views

Mini Review

Published on 09 Jan 2026

Beyond the amyloid hypothesis: leveraging human-centered complex in vitro models to decode Alzheimer’s disease etiology

in In Vitro Toxicology

Matthew Price
Francesca Pistollato

Frontiers in Toxicology

doi 10.3389/ftox.2025.1753572

2,003 views

Case Report

Published on 08 Jan 2026

Combined lipid emulsion and plasma exchange in massive pediatric bupropion overdose: Case Report

in Clinical Toxicology

Brett Russell
Michael Reedy
Kristina M. Flathers
Christine M. Matula
Erica Stevens
Friederike Strelow
Yosef Levenbrown

Frontiers in Toxicology

doi 10.3389/ftox.2025.1738642

795 views

Original Research

Published on 08 Jan 2026

Short-chain PFAS exposure during gestation and breastfeeding alters learning and memory in adulthood: possible mechanisms related to brain development

in Developmental and Reproductive Toxicology

Luca Lorenzini
Marzia Moretti
Claudia Zanardello
Federica Gallocchio
Vito A. Baldassarro
Alessandra Moressa
Lorenzo Zanella
Michele Sannia
Greta Foiani
Corinne Quadalti

Frontiers in Toxicology

doi 10.3389/ftox.2025.1702330

999 views

Original Research

Accepted on 05 Jan 2026

Microplastics amplify the pro-inflammatory response to fungal mycelial fragments and spores in neutrophil-like cells

in In Vitro Toxicology

Anani Komlavi Afanou
Andreas Solberg Sagen
Francesco Komlavi Barbero
Ilaria Komlavi Zanoni
Anna Komlavi Costa
Øyvind P Haugen
Shan Komlavi Zienolddiny-Narui

Frontiers in Toxicology

249 views

Original Research

Published on 05 Jan 2026

Comparative assessment of solvents toxicity using early life stages of amphibians and cell lines: a case study with dimethyl sulfoxide

in Environmental Toxicology

Sónia Dias Coelho
Diana Campos
Mónica Almeida
Carla Quintaneiro
Miguel Oliveira
Isabel Lopes

Frontiers in Toxicology

doi 10.3389/ftox.2025.1672301

804 views

Original Research

Published on 05 Jan 2026

Imidacloprid exposure in rats induces cardiac inflammatory response through activating TLR4/NF-κB/NLRP3 and JAK/STAT signaling pathways: focus on the berberine-loaded nanoliposomes

in Environmental Toxicology

Layla Alkharashi
Amina A. Farag
Noha M. Gamil
Yasmen F. Mahran
Amira M. Badr
Heba Bayoumi
Mahmoud Mostafa
Awatif A. Binmughram
Aljawharah F. Alquhayz
Gadah M. BinObaid

Frontiers in Toxicology

doi 10.3389/ftox.2025.1701021

1,501 views

Review

Published on 05 Jan 2026

Effects of atrazine on the HPG and HPA axes and steroidogenic pathways in females: relevance to reproductive function and breast, ovarian and uterine cancer

in Developmental and Reproductive Toxicology

Ralph L. Cooper
James W. Simpkins
Charles Breckenridge

Frontiers in Toxicology

doi 10.3389/ftox.2025.1686703

984 views
1 citation

Review

Accepted on 29 Dec 2025

Review of the Effect of Atrazine on the HPG Axes and Steroidogenic Pathways in Males: Relevance for Testicular and Prostate Cancer

in Environmental Toxicology

Ralph L. Cooper
James William Simpkins
Charles Breckenridge

Frontiers in Toxicology

320 views

Original Research

Published on 22 Dec 2025

Astragaloside IV ameliorates atrazine-induced male reproductive toxicity: an in vivo and in silico analysis

in Developmental and Reproductive Toxicology

Srinivasa Rao Sirasanagandla
Mohamed Al Mushaiqri
Firas Al-Majrafi
Nadia Al-Abri
Selvaraj Jayaraman
Isehaq Saif Al Huseini

Frontiers in Toxicology

doi 10.3389/ftox.2025.1692518

1,122 views

Original Research

Published on 18 Dec 2025

Beyond cytotoxicity: pollutant mixtures elicit unconventional epithelial-fibroblast signaling in a human lung air-liquid interface co-culture model

in In Vitro Toxicology

Justine Fredoc-Louison
Maëva Cherrière
Bastien Rival
Suzanne De Araujo
Sabine François
Samir Dekali

Frontiers in Toxicology

doi 10.3389/ftox.2025.1722968

1,020 views

Original Research

Published on 18 Dec 2025

MoltiTox: a multimodal fusion model for molecular toxicity prediction

in Computational Toxicology and Informatics

Junwoo Park
Sujee Lee

Frontiers in Toxicology

doi 10.3389/ftox.2025.1720651

1,341 views

Case Report

Published on 17 Dec 2025

Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review

in Clinical Toxicology

Wenzhen Zhou
Yuxin Sun
Mingcheng Dai
Senlin Ma
Qiuxin Lu
Junwei Qian
Zhaoming Shang
Kangshuai Zhou
Mingquan Chen
Xiaofei Jiang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1692362

1,107 views

Review

Published on 17 Dec 2025

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA’s RAAF, and good read-across practice

in Regulatory Toxicology

Thomas Hartung
Costanza Rovida

Frontiers in Toxicology

doi 10.3389/ftox.2025.1690491

1,837 views

Correction

Published on 16 Dec 2025

Correction: The impact of perfumes and cosmetic products on human health: a narrative review

in Environmental Toxicology

Sharifa Alblooshi

Frontiers in Toxicology

doi 10.3389/ftox.2025.1713750

1,387 views

Review

Published on 10 Dec 2025

Enhancing allergenicity risk assessment for novel foods in the EU: insights from the updated EFSA guidance - requirements, knowledge gaps and research needs

in Food and Nutritional Toxicology

Marcello Laganaro
Anna-Maria Pieger
Alejandra Muñoz-González
Estefanía Noriega Fernández
Ermolaos Ververis
Andrea Germini
Antonio Fernández Dumont

Frontiers in Toxicology

doi 10.3389/ftox.2025.1701391

1,900 views

Original Research

Published on 08 Dec 2025

Comparative evaluation of artificial saliva and complete artificial saliva as solvent vehicles for in vitro toxicity testing of oral tobacco products

in In Vitro Toxicology

Xuefei Cao
Mariana T. Farcas
Yevgeniya V. Prepelitskaya
Abaigeal Ritzenthaler
Jennifer Molignano
Jonathan Oldach
Marisol M. Gutierrez

Frontiers in Toxicology

doi 10.3389/ftox.2025.1657073

1,371 views

Case Report

Published on 05 Dec 2025

Cortical microstructural change linked to clinical recovery in subacute delayed encephalopathy after acute carbon monoxide poisoning: a longitudinal case report

in Clinical Toxicology

Takehiro Tamura
Yuka Fujimoto
Hironobu Nakamura
Yuki Takahashi
Junya Fujino
Shunsuke Takagi
Hidehiko Takahashi
Genichi Sugihara

Frontiers in Toxicology

doi 10.3389/ftox.2025.1701308

913 views

Data Report

Published on 05 Dec 2025

Wild mushroom poisoning in Mengzi city, Yunnan province, China, 2018–2023: an analysis through epidemiological characteristics and time series analysis with SARIMA and holt-winters models

in Food and Nutritional Toxicology

Rong Niu
Yimin Wang

Frontiers in Toxicology

doi 10.3389/ftox.2025.1705460

1,159 views

Original Research

Published on 05 Dec 2025

Thai rice instant granules containing turmeric extract and Phyllanthus emblica fruit pulp: Chronic toxicity and antioxidant profiles in rats and in silico investigation of bioactive compounds

in Food and Nutritional Toxicology

Charatda Punvittayagul
Atigan Thongtharb
Sonthaya Umsumarng
Siripat Chaichit
Siriporn Okonogi
Chadarat Ampasavate
Darunee Hongwiset
Sirinya Taya

Frontiers in Toxicology

doi 10.3389/ftox.2025.1691014

981 views

Original Research

Published on 04 Dec 2025

Monocyte migration assay using a vascular-on-a-chip model and its utilization for the evaluation of a heated tobacco product

in In Vitro Toxicology

Ayaka Hayashida
Atsuko Nozawa
Shigeaki Ito

Frontiers in Toxicology

doi 10.3389/ftox.2025.1658093

1,498 views

Original Research

Published on 04 Dec 2025

Simulation of microplastic transport and dispersion based on a three-dimensional hydrodynamic particle-tracking model in the Beibu Gulf

in Nanotoxicology

Changhao Sun
Yao Guan
Wenhao Hou
Huihua Wei
Xiaowei Hu
Huichang Jiang
Qiongyuan Su
Xiong Zhou
Jie Chen
Zuhao Zhu

Frontiers in Toxicology

doi 10.3389/ftox.2025.1676823

1,015 views

Original Research

Published on 03 Dec 2025

Retrospective analysis of clinical laboratory parameters in Han Wistar rat controls

in Computational Toxicology and Informatics

Rupert Kellner
Alexander Amberg
Frank Bringezu
Dragomir Ivanov Draganov
Annika Kreuchwig
Wolfgang Muster
Guillemette Duchateau-Nguyen
Nils Oberhauser
Paolo Piraino
Markus Schaefer

Frontiers in Toxicology

doi 10.3389/ftox.2025.1684191

935 views

636 articles

articles

Role of bisphenol A in the aberrant activation of ionotropic glutamate transporters in the cerebral cortex and altered behavioral responses in C57BL/6J mice

Food contaminants: mechanisms of toxicity, computational assessment, and mitigation

Beyond the amyloid hypothesis: leveraging human-centered complex in vitro models to decode Alzheimer’s disease etiology

Combined lipid emulsion and plasma exchange in massive pediatric bupropion overdose: Case Report

Short-chain PFAS exposure during gestation and breastfeeding alters learning and memory in adulthood: possible mechanisms related to brain development

Microplastics amplify the pro-inflammatory response to fungal mycelial fragments and spores in neutrophil-like cells

Comparative assessment of solvents toxicity using early life stages of amphibians and cell lines: a case study with dimethyl sulfoxide

Imidacloprid exposure in rats induces cardiac inflammatory response through activating TLR4/NF-κB/NLRP3 and JAK/STAT signaling pathways: focus on the berberine-loaded nanoliposomes

Effects of atrazine on the HPG and HPA axes and steroidogenic pathways in females: relevance to reproductive function and breast, ovarian and uterine cancer

Review of the Effect of Atrazine on the HPG Axes and Steroidogenic Pathways in Males: Relevance for Testicular and Prostate Cancer

Astragaloside IV ameliorates atrazine-induced male reproductive toxicity: an in vivo and in silico analysis

Beyond cytotoxicity: pollutant mixtures elicit unconventional epithelial-fibroblast signaling in a human lung air-liquid interface co-culture model

MoltiTox: a multimodal fusion model for molecular toxicity prediction

Alcohol-clozapine synergism triggering rhabdomyolysis at subtoxic levels: a case report and literature review

Mechanistic read-across comes of age: a comparative appraisal of EFSA 2025 guidance, ECHA’s RAAF, and good read-across practice

Correction: The impact of perfumes and cosmetic products on human health: a narrative review

Enhancing allergenicity risk assessment for novel foods in the EU: insights from the updated EFSA guidance - requirements, knowledge gaps and research needs

Comparative evaluation of artificial saliva and complete artificial saliva as solvent vehicles for in vitro toxicity testing of oral tobacco products

Cortical microstructural change linked to clinical recovery in subacute delayed encephalopathy after acute carbon monoxide poisoning: a longitudinal case report

Wild mushroom poisoning in Mengzi city, Yunnan province, China, 2018–2023: an analysis through epidemiological characteristics and time series analysis with SARIMA and holt-winters models

Thai rice instant granules containing turmeric extract and Phyllanthus emblica fruit pulp: Chronic toxicity and antioxidant profiles in rats and in silico investigation of bioactive compounds

Monocyte migration assay using a vascular-on-a-chip model and its utilization for the evaluation of a heated tobacco product

Simulation of microplastic transport and dispersion based on a three-dimensional hydrodynamic particle-tracking model in the Beibu Gulf

Retrospective analysis of clinical laboratory parameters in Han Wistar rat controls